The Istikhara done by a person does not bind other person even if they are husband and wife unless it was done by request from the husband and his wife was just doing it on his behalf and on his intention.
To answer your question, yes it is possible for a dua to change a given situation. With that said, i would caution against overuse of Istikharas. They should only be performed after one has utilized their intellect to the full extent, and they have consulted with others, and done everything within their reach to reach a solid conclusion. If they still haven't been able to reach a conclusion, only then should an Istikhara be utilized.
In some cultures in the Middle East, Istikharas are over utilized while God has given us an intellect for a reason....
It depends on the verses. Most results can be interpreted as "yes" or "no". Occasionally it does not give a strong view either way. You could ask someone for a second opinion on it. Generally the result of an istikhara does not come in the form of a command but rather is interpreted from the overall content and context of the verses.
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