Bismihi ta'ala
If your parents are anti-vaccination, or against the Covid vaccine specifically, and they do not wish to take the vaccination due to a medical condition, which you also suffer from, and out of fear of you getting worse, then you must consult with a specialist and see what they recommend.
If your parents are against Covid for any other reason, and not due to health difficulties you suffer from, then it would not be a sin if you take the vaccine without their knowledge. However, if they have specifically said to you that they will, for example, disown you if you get it, etc, then I would suggest you try to rationalise with them to avoid problems.
With prayers for your success.