Is it reasonable to justify mistreatment and hostility towards the achievements of Muslim women, by claiming that highlighting Bibi Khadijah's status as a working woman misguides others?
Saying that Bibi Khadijah was a working woman is not misguidance, it is a fact, and it is not misguided to speak a fact about those who were close to the Prophet (S).
However, although Bibi Khadijah was quite empowered, both financially and socially, simply saying this does not compensate for social injustice, including towards women. Rather, it is important to be honest about what goes on in the real world, and if something is not as it should be in society, attention should be called to that so that it can be changed. Of course, one can look to Bibi Khadijah or others as inspirations when doing that, and speak about both.