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Seyed Ali Musawi,
Seyed Ali Musawi studied religion and history at the University of California, San Diego and subsequently he studied for more than 8 years at the Islamic Seminary in Qum, Iran, focusing on Islamic history and jurisprudence. 12 Answers
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Sayyed Mohammad Al-Musawi,
Sayyed Mohammad al-Musawi is originally from Iraq and heads up the World Ahlul Bayt Islamic League in London. Other than being involved in various humanitarian projects, he frequently responds to religious questions. In the past, he has also spent significant time in India guiding the community. 4499 Answers
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To answer your question, yes it is possible for a dua to change a given situation. With that said, i would caution against overuse of Istikharas. They should only be performed after one has utilized their intellect to the full extent, and they have consulted with others, and done everything within their reach to reach a solid conclusion. If they still haven't been able to reach a conclusion, only then should an Istikhara be utilized.
In some cultures in the Middle East, Istikharas are over utilized while God has given us an intellect for a reason....
Istekhara can not be repeated on the same matter unless the circumstances change. Du'a can help in changing the circumstances then another Istekhara can be seen.
Wassalam.